Harm Reduction: MDMA pleasure and Harm Reduction (2) - Revision history

Luma: /* Pre-load and post-load */

2025-07-31T10:40:10Z

Pre-load and post-load

← Older revision		Revision as of 10:40, 31 July 2025
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	However, this release is also believed to be the cause of the acute adverse effects that occur 24-48 hours after consumption. This includes depressed mood and fatigue, as well as the potential neurotoxic effects.		However, this release is also believed to be the cause of the acute adverse effects that occur 24-48 hours after consumption. This includes depressed mood and fatigue, as well as the potential neurotoxic effects.

	Some users turn to herbal supplements or tryptophan-rich foods to combat these adverse effects: chocolate, peanuts, or bananas. Typical ~~«post~~-load ~~formulas»~~ contain Vitamin C, magnesium, alpha-lipoic acid or green tea extract.These guidelines are based on recommendations in Internet forums or some books on MDMA.		Some users turn to herbal supplements or tryptophan-rich foods to combat these adverse effects: chocolate, peanuts, or bananas. Typical <strong>post-load formulas</strong> contain Vitamin C, magnesium, alpha-lipoic acid or green tea extract.These guidelines are based on recommendations in Internet forums or some books on MDMA.

	Pre-loading (before consuming MDMA) seeks to enhance the effects of the substance by theoretically increasing the amount of serotonin available.		Pre-loading (before consuming MDMA) seeks to enhance the effects of the substance by theoretically increasing the amount of serotonin available.

Luma: /* Pre-load and post-load */

2025-07-31T10:39:51Z

Pre-load and post-load

← Older revision		Revision as of 10:39, 31 July 2025
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	Post-loading (after consuming MDMA) aims to help the body recover from the potential adverse effects of MDMA: neurotoxicity, oxidative stress, and depletion of certain neurotransmitters , linked to depression and other adverse effects.		Post-loading (after consuming MDMA) aims to help the body recover from the potential adverse effects of MDMA: neurotoxicity, oxidative stress, and depletion of certain neurotransmitters , linked to depression and other adverse effects.

	Interestingly, the ~~«midweek blues»~~ have only been reported in recreational users, while therapeutic use has been associated with an ~~«afterglow»~~ in which residual empathogenic effects remain 24-48 hours longer. So this implies that the ~~«crash»~~ of MDMA has more to do with contextual aspects (lack of sleep, physical exercise, mixing with other substances…) than with its pharmacology.		Interestingly, the <strong>midweek blues</strong> have only been reported in recreational users, while therapeutic use has been associated with an <strong>afterglow</strong> in which residual empathogenic effects remain 24-48 hours longer. So this implies that the <strong>crash</strong> of MDMA has more to do with contextual aspects (lack of sleep, physical exercise, mixing with other substances…) than with its pharmacology.

	Thus, users who use moderate doses and frequencies, occasionally, programmed and without too many excesses should not suffer very accentuated acute psychological adverse effects. There is also no evidence that, in the usual consumption patterns in humans, MDMA produces irreversible neurotoxic damage. On the contrary, heavy users are more prone to such effects.		Thus, users who use moderate doses and frequencies, occasionally, programmed and without too many excesses should not suffer very accentuated acute psychological adverse effects. There is also no evidence that, in the usual consumption patterns in humans, MDMA produces irreversible neurotoxic damage. On the contrary, heavy users are more prone to such effects.

	So, data to support the use of post-load supplements are based on users' subjective experience. There have yet to be clinical trials that have evaluated this type of strategy. And there needs to be a consensus on appropriate dosages. Some authors recommend ~~«50~~ mg of 5-HTP for 3 days 24 hours after the last ~~intake»~~. Others use doses of 100-300 mg for 5-7 days.		So, data to support the use of post-load supplements are based on users' subjective experience. There have yet to be clinical trials that have evaluated this type of strategy. And there needs to be a consensus on appropriate dosages. Some authors recommend <strong>50 mg of 5-HTP for 3 days 24 hours after the last intake</strong>. Others use doses of 100-300 mg for 5-7 days.

	Post-MDMA intake of bananas, peanuts, or chocolate is unlikely to have any consequence (unless overindulged)		Post-MDMA intake of bananas, peanuts, or chocolate is unlikely to have any consequence (unless overindulged)

	With the available data, it is impossible to recommend a guideline or consider its efficacy. Then, a diet rich in bananas, peanuts, and chocolate is unlikely to have any negative impact after taking MDMA. But it has not been shown to affect either moderate users (in whom it is probably unnecessary) or intensive users (in whom it is probably ineffective for its intended purposes).		With the available data, it is impossible to recommend a guideline or consider its efficacy. Then, a diet rich in bananas, peanuts, and chocolate is unlikely to have any negative impact after taking MDMA. But it has not been shown to affect either moderate users (in whom it is probably unnecessary) or intensive users (in whom it is probably ineffective for its intended purposes).

	== Combinations with other drugs ==		== Combinations with other drugs ==
	The use of MDMA in combination with other drugs is very frequent, especially in recreational contexts. In general, when MDMA is combined with other drugs, its effects are modified, intensifying certain qualities and diminishing others. Combinations of drugs are generally considered undesirable because they distort the authentic experience induced by ecstasy, as well as increasing the risks. But it is also true that many people seek precisely certain effects from combinations, which can add to the experience.		The use of MDMA in combination with other drugs is very frequent, especially in recreational contexts. In general, when MDMA is combined with other drugs, its effects are modified, intensifying certain qualities and diminishing others. Combinations of drugs are generally considered undesirable because they distort the authentic experience induced by ecstasy, as well as increasing the risks. But it is also true that many people seek precisely certain effects from combinations, which can add to the experience.

Luma: /* MDMA and sex */

2025-07-31T10:38:47Z

MDMA and sex

← Older revision		Revision as of 10:38, 31 July 2025
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	== MDMA and sex ==		== MDMA and sex ==
	Opinions about sex on MDMA vary widely. It is often a matter of personal preference. But, indeed, it is one of the ~~«classical»~~ combinations for sex and drugs. Generally, people prefer engaging in sexual activity 3-4 hours after taking MDMA. At this point, the intense mental effects are beginning to subside, but the sensations of enhanced tactile stimulation and general well-being persist.		Opinions about sex on MDMA vary widely. It is often a matter of personal preference. But, indeed, it is one of the <strong>classical</strong> combinations for sex and drugs. Generally, people prefer engaging in sexual activity 3-4 hours after taking MDMA. At this point, the intense mental effects are beginning to subside, but the sensations of enhanced tactile stimulation and general well-being persist.

	One potential issue for men is that MDMA can make it more challenging to achieve and maintain an erection. However, this effect diminishes after three to four hours for most people. Some people counteract this effect using anti-impotence drugs. This is an option in healthy persons and using reasonable dosages.		One potential issue for men is that MDMA can make it more challenging to achieve and maintain an erection. However, this effect diminishes after three to four hours for most people. Some people counteract this effect using anti-impotence drugs. This is an option in healthy persons and using reasonable dosages.

Luma: /* Credits */

2025-07-27T22:44:23Z

Credits

← Older revision		Revision as of 22:44, 27 July 2025
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	Ultraviolet-visible spectroscopy (UV-Vis). <br>		Ultraviolet-visible spectroscopy (UV-Vis). <br>
	== Credits ==		== Credits ==
	Full credit goes towards [[Prominent: DoctorX\|DoctorX]] on Dread! (sourced from /post/~~376c35f4a2a1191348f5~~) - http://www.doctorcaudevilla.com/doctorx		Full credit goes towards [[Prominent: DoctorX\|DoctorX]] on Dread! (sourced from /post/ca93ffda5e25e2181f05) - http://www.doctorcaudevilla.com/doctorx

Luma: /* Credits */

2025-07-27T22:43:51Z

Credits

← Older revision		Revision as of 22:43, 27 July 2025
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	Ultraviolet-visible spectroscopy (UV-Vis). <br>		Ultraviolet-visible spectroscopy (UV-Vis). <br>
	== Credits ==		== Credits ==
	Full credit goes towards [[Prominent: DoctorX\|DoctorX]] on Dread! (sourced from /post/~~ca93ffda5e25e2181f05~~) - http://www.doctorcaudevilla.com/doctorx		Full credit goes towards [[Prominent: DoctorX\|DoctorX]] on Dread! (sourced from /post/376c35f4a2a1191348f5) - http://www.doctorcaudevilla.com/doctorx

Luma: /* Credits */

2025-07-27T20:54:22Z

Credits

← Older revision		Revision as of 20:54, 27 July 2025
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	Ultraviolet-visible spectroscopy (UV-Vis). <br>		Ultraviolet-visible spectroscopy (UV-Vis). <br>
	== Credits ==		== Credits ==
	Full credit goes towards DoctorX on Dread! (sourced from /post/ca93ffda5e25e2181f05) - http://www.doctorcaudevilla.com/doctorx		Full credit goes towards [[Prominent: DoctorX\|DoctorX]] on Dread! (sourced from /post/ca93ffda5e25e2181f05) - http://www.doctorcaudevilla.com/doctorx

Luma: /* Credits */

2025-07-27T11:58:57Z

Credits

← Older revision		Revision as of 11:58, 27 July 2025
Line 127:		Line 127:
	Ultraviolet-visible spectroscopy (UV-Vis). <br>		Ultraviolet-visible spectroscopy (UV-Vis). <br>
	== Credits ==		== Credits ==
			Full credit goes towards DoctorX on Dread! (sourced from /post/ca93ffda5e25e2181f05) - http://www.doctorcaudevilla.com/doctorx

Luma: /* Drug Checking */

2025-07-27T11:58:51Z

Drug Checking

← Older revision		Revision as of 11:58, 27 July 2025
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	Enzyme-Linked Immunosorbent Assay (ELISA) <br>		Enzyme-Linked Immunosorbent Assay (ELISA) <br>
	Ultraviolet-visible spectroscopy (UV-Vis). <br>		Ultraviolet-visible spectroscopy (UV-Vis). <br>
			== Credits ==

Luma: /* Drug Checking */

2025-07-27T11:58:07Z

Drug Checking

← Older revision		Revision as of 11:58, 27 July 2025
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	With proper calibration and validation, FTIR can still provide semi-quantitative information about the concentration of MDMA in a sample. However, FTIR is not a highly sensitive technique and may not be suitable for detecting trace amounts of MDMA in complex mixtures. Therefore, it's important to use complementary techniques such as TLC or GC-MS to confirm the presence of MDMA in a sample. It's important to note that the sensitivity and accuracy of the results will depend on the specific instrument, sample preparation, and analytical method used.		With proper calibration and validation, FTIR can still provide semi-quantitative information about the concentration of MDMA in a sample. However, FTIR is not a highly sensitive technique and may not be suitable for detecting trace amounts of MDMA in complex mixtures. Therefore, it's important to use complementary techniques such as TLC or GC-MS to confirm the presence of MDMA in a sample. It's important to note that the sensitivity and accuracy of the results will depend on the specific instrument, sample preparation, and analytical method used.

	<strong>Quantification:</strong>		<strong>Quantification:</strong><br>
	Quantification (knowing the exact amount of MDMA in a particular pill or the percentage in a crystal sample) requires much more complicated analysis. Some available techniques are:		Quantification (knowing the exact amount of MDMA in a particular pill or the percentage in a crystal sample) requires much more complicated analysis. Some available techniques are:

	High Performance Liquid Chromatography (HPLC)		High Performance Liquid Chromatography (HPLC) <br>
	Gas Chromatography-Mass Spectrometry (GC-MS)		Gas Chromatography-Mass Spectrometry (GC-MS) <br>
	Enzyme-Linked Immunosorbent Assay (ELISA		Enzyme-Linked Immunosorbent Assay (ELISA) <br>
	Ultraviolet-visible spectroscopy (UV-Vis).		Ultraviolet-visible spectroscopy (UV-Vis). <br>

Luma: /* Drug Checking */

2025-07-27T11:57:37Z

Drug Checking

← Older revision		Revision as of 11:57, 27 July 2025
Line 118:		Line 118:

	With proper calibration and validation, FTIR can still provide semi-quantitative information about the concentration of MDMA in a sample. However, FTIR is not a highly sensitive technique and may not be suitable for detecting trace amounts of MDMA in complex mixtures. Therefore, it's important to use complementary techniques such as TLC or GC-MS to confirm the presence of MDMA in a sample. It's important to note that the sensitivity and accuracy of the results will depend on the specific instrument, sample preparation, and analytical method used.		With proper calibration and validation, FTIR can still provide semi-quantitative information about the concentration of MDMA in a sample. However, FTIR is not a highly sensitive technique and may not be suitable for detecting trace amounts of MDMA in complex mixtures. Therefore, it's important to use complementary techniques such as TLC or GC-MS to confirm the presence of MDMA in a sample. It's important to note that the sensitivity and accuracy of the results will depend on the specific instrument, sample preparation, and analytical method used.

			<strong>Quantification:</strong>
			Quantification (knowing the exact amount of MDMA in a particular pill or the percentage in a crystal sample) requires much more complicated analysis. Some available techniques are:

			High Performance Liquid Chromatography (HPLC)
			Gas Chromatography-Mass Spectrometry (GC-MS)
			Enzyme-Linked Immunosorbent Assay (ELISA
			Ultraviolet-visible spectroscopy (UV-Vis).